Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18833378 | 0.87 | PLD1 (0.52) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3154404 | 0.84 | HRH4 (0.51) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3658830 | 0.84 | HRH4 (0.51) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3153901 | 0.84 | HRH4 (0.51) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL28170653 | 0.83 | MAP4K4 (0.49) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31549832 | 0.83 | MAP4K4 (0.49) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL1402090 | 0.83 | HRH4 (0.50) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31441374 | 0.83 | PLD1 (0.53) | PLD1KDM4EGPR119SMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL1402092 | 0.83 | HRH4 (0.50) | PLD1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23875675 | 0.81 | GRM1 (0.51) | PLD1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523954-B1 | 1H-[1,2,3]TRIAZOLO[4,5-C]PYRIDINE-4- CARBONITRILE DERIVATIVES AS CATHEPSIN S INHIBITORS | MERCK SHARP & DOHME (NL) | 2014-04-16 | — | — | EP | disclosed |