Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31549832 | 1.00 | MAP4K4 (0.49) | MAP4K4DPP4DPP8DPP9DPP7 | |
| SCHEMBL30641568 | 0.90 | PLD1 (0.53) | PLD1HTTAVPR1APDE10AGPR119 | |
| SCHEMBL30641563 | 0.90 | PLD1 (0.53) | PLD1HTTAVPR1APDE10AGPR119 | |
| SCHEMBL16543107 | 0.84 | GRM1 (0.57) | PLD1GRM1AVPR1AUSP30GPR119 | |
| SCHEMBL16474292 | 0.83 | PLD1 (0.51) | PLD1GRM1AVPR1AUSP30GPR119 | |
| SCHEMBL17619606 | 0.81 | GPR119 (0.52) | PLD1GRM1HTTAVPR1AGPR119 | |
| SCHEMBL28136848 | 0.80 | KDM4E (0.45) | MAP4K4DPP4DPP8DPP9DPP7 | |
| SCHEMBL16785630 | 0.78 | MAP4K4 (0.46) | MAP4K4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL896038 | 0.76 | DPP4 (0.51) | DPP4DPP8DPP9DPP7GRM1 | |
| SCHEMBL25253230 | 0.76 | MAP4K4 (0.50) | MAP4K4PDE10AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207496-A | Substituted bridged ring urea analogs as sirtuin modulators | 葛兰素史密斯克莱有限责任公司 | 2017-09-26 | — | — | CN | disclosed |