Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 5/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1963687 | 0.82 | DPP4 (0.36) | DPP4ALPLCRHR1GSK3BGSK3A | |
| SCHEMBL12680892 | 0.75 | GSK3B (0.36) | DPP4ALPLGSK3BGSK3ACNR1 | |
| SCHEMBL12680888 | 0.74 | ADORA2A (0.40) | DPP4GSK3BGSK3ACNR1DPP8 | |
| SCHEMBL12680846 | 0.73 | ALPL (0.37) | DPP4ALPLGSK3BGSK3ACNR1 | |
| SCHEMBL1119573 | 0.73 | DPP4 (0.36) | DPP4GSK3BGSK3ACDK1 | |
| SCHEMBL1960159 | 0.72 | GSK3B (0.39) | DPP4ALPLGSK3BGSK3ACNR1 | |
| SCHEMBL1964817 | 0.72 | GSK3B (0.33) | DPP4GSK3BGSK3A | |
| SCHEMBL9105999 | 0.72 | GSK3B (0.39) | DPP4ALPLGSK3BGSK3ACDK1 | |
| SCHEMBL12680862 | 0.71 | GSK3B (0.36) | ALPLGSK3BGSK3ACDK1ALPG | |
| SCHEMBL12680864 | 0.71 | GSK3B (0.38) | DPP4ALPLGSK3BGSK3ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280976-B1 | SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AS GSK3BETA-INHIBITORS | BAYER IP GMBH (DE) | 2014-01-01 | — | — | EP | disclosed |