Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647534 | 0.77 | MAPT (0.37) | MAPTALDH1A1LMNAKMT2AHTT | |
| SCHEMBL2231864 | 0.74 | POLB (0.47) | MAPTALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2231547 | 0.71 | MAPT (0.48) | MAPTALDH1A1KMT2AHTTJAK2 | |
| SCHEMBL942774 | 0.70 | MAPT (0.52) | MAPTALDH1A1KMT2AHTTJAK2 | |
| SCHEMBL942649 | 0.69 | MAPT (0.45) | MAPTALDH1A1LMNAHTTMMP14 | |
| SCHEMBL943658 | 0.69 | MAPT (0.57) | MAPTALDH1A1KMT2AHTTJAK2 | |
| SCHEMBL1645614 | 0.66 | NPC1 (0.56) | MAPTALDH1A1LMNAKMT2AHTT | |
| SCHEMBL16730044 | 0.66 | MAPT (0.58) | MAPTALDH1A1LMNAKMT2AHTT | |
| SCHEMBL2231651 | 0.65 | MAPT (0.42) | MAPTALDH1A1LMNAKMT2AHTT | |
| SCHEMBL1993805 | 0.65 | MAPT (0.45) | MAPTALDH1A1KMT2AHTTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303329-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G Limited (GB) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009144473-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |