Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16476506 | 1.00 | MKNK1 (0.46) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL16476508 | 0.92 | MKNK1 (0.54) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL14877634 | 0.78 | PDE4D (0.43) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL17353216 | 0.78 | SCD (0.44) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL15696504 | 0.78 | PDE4D (0.43) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL2409363 | 0.78 | NTRK1 (0.42) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL17353214 | 0.78 | SCD (0.44) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL15468356 | 0.78 | PDE4D (0.43) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL2406263 | 0.78 | NTRK1 (0.42) | MKNK1MKNK2EIF4EPDE4DNTRK1 | |
| SCHEMBL2406266 | 0.78 | NTRK1 (0.42) | MKNK1MKNK2EIF4EPDE4DNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539346-B1 | 4-[HETEROCYCLOALKYLOXY(HETERO)ARYLAMINO] THIENO[2,3-D]PYRIMIDINES HAVING MNK1/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2014-04-16 | — | — | EP | disclosed |