Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 3/20 | 0.62 |
| ▸ | PRKACG | P22612 | 3/20 | 0.62 |
| ▸ | PRKACB | P22694 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12779302 | 0.84 | ROCK2 (0.78) | ROCK2ROCK1SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL12779305 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL3810618 | 0.82 | ROCK2 (0.75) | ROCK2ROCK1PRKACAADORA3ADORA2A | |
| SCHEMBL1649591 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1647159 | 0.78 | ROCK2 (0.62) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1647555 | 0.78 | ROCK1 (0.58) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL23255661 | 0.78 | ROCK2 (0.63) | ROCK2ROCK1SMN1; SMN2PRKACAPRKACG | |
| SCHEMBL3120901 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1ADORA3ADORA2AADORA2B | |
| SCHEMBL1647630 | 0.77 | ROCK1 (0.73) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1648224 | 0.77 | ROCK1 (0.61) | ROCK2ROCK1PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |