Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 7/20 | 0.65 |
| ▸ | NQO1 | P15559 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957547 | 0.90 | VKORC1 (0.63) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL1647670 | 0.88 | VKORC1 (0.64) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL1649128 | 0.88 | ALDH1A1 (0.66) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL1648184 | 0.88 | VKORC1 (0.72) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL4399497 | 0.86 | VKORC1 (0.58) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL1648114 | 0.85 | VKORC1 (0.62) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL3171054 | 0.85 | VKORC1 (0.61) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL1647701 | 0.84 | VKORC1 (0.58) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL13498436 | 0.83 | VKORC1 (0.62) | VKORC1NQO1ALDH1A1MEN1ABCB11 | |
| SCHEMBL3174074 | 0.83 | TSHR (0.56) | VKORC1NQO1ALDH1A1MEN1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161261-B1 | Materials and methods for treating coagulation disorders | ARMETHEON INC (US) | 2013-08-28 | — | — | EP | disclosed |
| US-7932405-B2 | Halogenated ester derivatives of coumarins for the treatment of coagulation disorders | ARYX THERAPEUTICS, INC. (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2161261-A1 | Materials and methods for treating coagulation disorders | Aryx Therapeutics (US) | 2010-03-10 | — | — | EP | disclosed |
| EP-1735296-B1 | MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS | ARYX THERAPEUTICS (US) | 2009-12-09 | — | — | EP | disclosed |