Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18345852 | 0.91 | TAAR1 (0.59) | MAPTTAAR1HSD17B10NISCHADRA2A | |
| SCHEMBL6627508 | 0.82 | MAPT (0.75) | MAPTHSD17B10KMT2AKDM4E | |
| SCHEMBL1004931 | 0.82 | MAPT (0.70) | MAPTHSD17B10KMT2APARP1KDM4E | |
| SCHEMBL3476066 | 0.81 | NISCH (0.62) | MAPTTAAR1HSD17B10NISCHADRA2A | |
| SCHEMBL29773845 | 0.81 | NISCH (0.62) | MAPTTAAR1HSD17B10NISCHADRA2A | |
| SCHEMBL12927815 | 0.81 | MAPT (0.68) | MAPTHSD17B10KMT2APARP1KDM4E | |
| SCHEMBL411353 | 0.78 | MAPT (0.64) | MAPTTAAR1HSD17B10RAD52KMT2A | |
| SCHEMBL620253 | 0.78 | TAAR1 (0.78) | TAAR1NISCHPARP1KDM4EHTR5A | |
| Hydrochloric Acid SCHEMBL18345594 | 0.77 | TAAR1 (0.62) | MAPTTAAR1HSD17B10RAD52KMT2A | |
| SCHEMBL10155124 | 0.73 | PARP1 (0.56) | MAPTTAAR1RAD52KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448585-B1 | AZINONE-SUBSTITUTED AZEPINO[B]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RES INC (US) | 2014-01-01 | — | — | EP | disclosed |