Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 2/20 | 0.63 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.63 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1974056 | 1.00 | PRKAG1 (0.63) | PRKAG1PRKAA1PRKAB1SMN1; SMN2TP53 | |
| SCHEMBL1973983 | 1.00 | PRKAG1 (0.63) | PRKAG1PRKAA1PRKAB1SMN1; SMN2TP53 | |
| SCHEMBL1973985 | 1.00 | PRKAG1 (0.63) | PRKAG1PRKAA1PRKAB1SMN1; SMN2TP53 | |
| SCHEMBL12580518 | 0.93 | PRKAG1 (0.53) | PRKAG1PRKAA1PRKAB1BCL2 | |
| SCHEMBL12580514 | 0.93 | PRKAG1 (0.53) | PRKAG1PRKAA1PRKAB1BCL2 | |
| SCHEMBL1974484 | 0.90 | PRKAG1 (0.52) | PRKAG1PRKAA1PRKAB1SMN1; SMN2IDH1 | |
| SCHEMBL1973761 | 0.90 | PRKAG1 (0.51) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL1977138 | 0.90 | PRKAG1 (0.52) | PRKAG1PRKAA1PRKAB1SMN1; SMN2IDH1 | |
| SCHEMBL1973760 | 0.90 | PRKAG1 (0.51) | PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL1977870 | 0.90 | PRKAG1 (0.52) | PRKAG1PRKAA1PRKAB1SMN1; SMN2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509946-B1 | SPIRO INDOLE-CYCLOPROPANE INDOLINONES USEFUL AS AMPK MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-04-16 | — | — | EP | disclosed |