Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 11/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | LIPC | P11150 | 3/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16478320 | 0.88 | CTSC (0.47) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16485798 | 0.85 | CTSC (0.60) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16478330 | 0.85 | CTSC (0.60) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16478373 | 0.84 | CTSC (0.49) | CTSCKCNH2CTSK | |
| SCHEMBL16485816 | 0.84 | CTSC (0.69) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16478302 | 0.84 | CTSC (0.69) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16485799 | 0.83 | TACR2 (0.41) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16478231 | 0.79 | CTSC (0.59) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16485837 | 0.79 | CTSC (0.64) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL16478232 | 0.77 | CTSC (0.64) | CTSCKCNH2LTB4RLTB4R2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011154677-A1 | SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760 | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | WO | claimed |
| WO-2011154677-A1 | SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760 | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | WO | disclosed |