⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16532437 | 1.00 | — | — | |
| SCHEMBL16179443 | 1.00 | — | — | |
| SCHEMBL23168692 | 0.86 | GRIN1 (0.40) | — | |
| SCHEMBL19174271 | 0.86 | GRIN1 (0.40) | — | |
| SCHEMBL16478701 | 0.78 | — | — | |
| SCHEMBL761689 | 0.75 | — | — | |
| SCHEMBL23168693 | 0.75 | — | — | |
| SCHEMBL16498173 | 0.75 | — | — | |
| SCHEMBL22591736 | 0.74 | — | — | |
| SCHEMBL8998692 | 0.73 | GRIN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230339952-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-10-26 | — | — | US | disclosed |
| EP-4223752-A1 | DEUTERATED HPK1 KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Zhuhai Yufan Biotechnologies Co., Ltd (CN) | 2023-08-09 | — | — | EP | disclosed |
| US-20230241050-A1 | APPLICATIONS OF HPK1 KINASE INHIBITOR IN PREVENTING AND/OR TREATING ANIMAL PATHOGEN INFECTION | Guangzhou Yufan Nantu Biotechnologies Co., Ltd (CN) | 2023-08-03 | — | — | US | disclosed |
| EP-3781563-B1 | HPK1 INHIBITORS, PREPARATION METHOD AND APPLICATION THEREOF | ZHUHAI YUFAN BIOTECHNOLOGIES CO LTD (CN) | 2022-06-29 | — | — | EP | disclosed |
| WO-2022081912-A2 | HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2021057872-A1 | PROTAC SMALL MOLECULE COMPOUND AND APPLICATION THEREOF | 珠海宇繁生物科技有限责任公司 | 2021-04-01 | — | — | WO | disclosed |
| EP-3307741-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARIC M2 RECEPTOR | Bayer Pharma AG (DE) | 2020-10-28 | — | — | EP | disclosed |
| WO-2016198342-A1 | POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-15 | — | — | WO | disclosed |
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140011800-A1 | PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRISTOL-MYERS SQUIBB COMPANY | 2014-01-09 | — | — | US | disclosed |