Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cetirizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.95 |
| ▸ | DRD3 | P35462 | 5/20 | 0.95 |
| ▸ | USP2 | O75604 | 3/20 | 0.95 |
| ▸ | HRH2 | P25021 | 2/20 | 0.95 |
| ▸ | HTR2A | P28223 | 2/20 | 0.95 |
| ▸ | HTR2B | P41595 | 2/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.95 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.95 |
| ▸ | TEK | Q02763 | 1/20 | 0.95 |
| ▸ | DRD2 | P14416 | 4/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.71 |
| ▸ | DRD4 | P21917 | 1/20 | 0.71 |
| ▸ | HTR7 | P34969 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cetirizine SCHEMBL1231124 | 0.99 | DRD3 (0.98) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL2455487 | 0.98 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL5526985 | 0.98 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL4176 | 0.98 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL13724610 | 0.98 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Levocetirizine SCHEMBL4914 | 0.98 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Levocetirizine SCHEMBL5935097 | 0.98 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Levocetirizine SCHEMBL2255374 | 0.97 | HRH1 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Levocetirizine SCHEMBL2432644 | 0.97 | DRD3 (0.98) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL6474316 | 0.97 | DRD3 (0.98) | DRD3HRH1USP2HRH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117821168-A | Semiconductor chip cleaning liquid, preparation method and application thereof | 浙江奥首材料科技有限公司 | 2024-04-05 | — | — | CN | disclosed |
| US-20220331257-A1 | LIQUID PHARMACEUTICAL COMPOSITIONS WITH STABLE DRUG RELEASE PROFILES | AVADEL LEGACY PHARMACEUTICALS, LLC | 2022-10-20 | — | — | US | disclosed |
| US-20170001988-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2017-01-05 | — | — | US | disclosed |
| CN-106029060-A | piperidine and piperidine derivatives and their use in the treatment of viral infections and cancer | 美国卫生和人力服务部 | 2016-10-12 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170001988-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER | NCOR1, RRP15, NCOA1 | HRH1 100/4885DRD3 584/4885USP2 3001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.