Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levocetirizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 5/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | HRH2 | P25021 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | TEK | Q02763 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.74 |
| ▸ | DRD4 | P21917 | 1/20 | 0.74 |
| ▸ | HTR7 | P34969 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cetirizine SCHEMBL13724610 | 1.00 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Levocetirizine SCHEMBL4914 | 1.00 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL2455487 | 1.00 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL5526985 | 1.00 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL4176 | 1.00 | DRD3 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL6474316 | 0.99 | DRD3 (0.98) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL2430457 | 0.99 | DRD3 (0.98) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL41107 | 0.99 | HRH1 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Levocetirizine SCHEMBL2255374 | 0.99 | HRH1 (1.00) | DRD3HRH1USP2HRH2HTR2A | |
| Cetirizine SCHEMBL5520719 | 0.99 | HRH1 (1.00) | DRD3HRH1USP2HRH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060083786-A1 | Taste masking pharmaceutical composition containing levocetirizine | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2006-04-20 | — | — | US | disclosed |