Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LCAT | P04180 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9891785 | 0.83 | HRH3 (0.44) | HRH3ALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL9108258 | 0.82 | IDH1 (0.43) | HRH3ALDH1A1L3MBTL1KDM4EPOLB | |
| SCHEMBL9108249 | 0.82 | IDH1 (0.43) | HRH3ALDH1A1L3MBTL1KDM4EPOLB | |
| SCHEMBL16480457 | 0.82 | NPC1 (0.45) | HRH3ALDH1A1NPSR1ABL1 | |
| SCHEMBL9893027 | 0.81 | GRM5 (0.42) | HRH3ABL1GRM5 | |
| SCHEMBL13285315 | 0.81 | GRIN2D (0.38) | HRH3MAPTABL1GRM5 | |
| SCHEMBL9893029 | 0.81 | GAA (0.44) | ALDH1A1KDM4EMAPTNPSR1CYP1A2 | |
| SCHEMBL9892984 | 0.78 | POLB (0.54) | ALDH1A1L3MBTL1POLBCYP1A2CYP3A4 | |
| SCHEMBL9892997 | 0.77 | MAPT (0.51) | HRH3ALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL9893014 | 0.77 | CNR1 (0.50) | ALDH1A1L3MBTL1KDM4EGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384320-B1 | PYRROLIDINE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2015-03-04 | — | — | EP | disclosed |
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |