Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 10/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13889403 | 0.81 | MCL1 (0.52) | MCL1L3MBTL1FFAR4LTA4HPPARG | |
| SCHEMBL19433595 | 0.78 | MCL1 (0.64) | MCL1L3MBTL1FFAR4ALDH1A1TSHR | |
| SCHEMBL11586955 | 0.78 | MCL1 (0.71) | MCL1L3MBTL1FFAR4ALDH1A1MEN1 | |
| SCHEMBL15464819 | 0.76 | MCL1 (0.70) | MCL1L3MBTL1MAPTALDH1A1HPGD | |
| SCHEMBL17711011 | 0.75 | MAPT (0.53) | MCL1L3MBTL1FFAR4MAPTALDH1A1 | |
| SCHEMBL16503434 | 0.74 | MCL1 (0.68) | MCL1L3MBTL1HPGDTSHR | |
| SCHEMBL3731595 | 0.73 | L3MBTL1 (0.67) | MCL1L3MBTL1HPGDTSHRMEN1 | |
| SCHEMBL1350610 | 0.73 | MCL1 (0.56) | MCL1L3MBTL1FFAR4LTA4HTSHR | |
| SCHEMBL24217682 | 0.73 | MCL1 (0.57) | MCL1L3MBTL1FFAR4MAPTLTA4H | |
| SCHEMBL3723832 | 0.72 | L3MBTL1 (0.66) | MCL1L3MBTL1HPGDTSHRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629141-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-01-14 | — | — | US | disclosed |