Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479301 | 0.78 | MAPT (0.57) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL31211203 | 0.78 | MAPT (0.57) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL5946197 | 0.78 | MAPT (0.57) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL12715606 | 0.77 | MAPT (0.45) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL15906147 | 0.77 | MAPT (0.55) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL28062197 | 0.77 | MAPT (0.58) | MAPTNPSR1CYP3A4GAACA2 | |
| SCHEMBL16047636 | 0.75 | MAPT (0.53) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL30254383 | 0.75 | MAPT (0.53) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL30542553 | 0.75 | MAPT (0.53) | MAPTNPSR1POLBL3MBTL1EP300 | |
| SCHEMBL6744216 | 0.75 | MAPT (0.53) | MAPTNPSR1POLBL3MBTL1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014058747-A1 | 5-PHENOXY-3H-PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-04-17 | — | — | WO | disclosed |