Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408832 | 0.75 | NPC1 (0.59) | IRAK4KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL20686571 | 0.74 | IRAK4 (0.70) | IRAK4 | |
| SCHEMBL18472783 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL16481683 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL16466564 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL16481626 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL21106093 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL20686559 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL16481548 | 0.73 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL25968374 | 0.73 | IRAK4 (1.00) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598440-B2 | Inhibitors of IRAK4 activity | MERCK SHARP & DOHME CORP. (US) | 2017-03-21 | — | — | US | disclosed |
| WO-2014058685-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2014-04-17 | — | — | WO | disclosed |