Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | ALB | P02768 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | NQO1 | P15559 | 3/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1649099 | 0.87 | CYP2C9 (0.57) | CYP2C9ALBHSD17B10ALDH1A1VKORC1 | |
| SCHEMBL1647638 | 0.85 | CYP2C9 (0.72) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 | |
| SCHEMBL1647664 | 0.82 | NQO1 (0.65) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 | |
| SCHEMBL3157772 | 0.81 | CYP2C9 (0.60) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 | |
| SCHEMBL14078679 | 0.81 | TOP2A (0.62) | CYP2C9ALBHSD17B10ALDH1A1VKORC1 | |
| SCHEMBL14170275 | 0.79 | NQO1 (0.69) | CYP2C9ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5149518 | 0.78 | ADORA3 (0.51) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 | |
| SCHEMBL1648320 | 0.77 | ADORA3 (0.70) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 | |
| SCHEMBL5113240 | 0.77 | CYP2C9 (0.69) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 | |
| SCHEMBL1647648 | 0.75 | ADORA3 (0.67) | ADORA3CYP2C9ALBHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161261-B1 | Materials and methods for treating coagulation disorders | ARMETHEON INC (US) | 2013-08-28 | — | — | EP | disclosed |
| US-7932405-B2 | Halogenated ester derivatives of coumarins for the treatment of coagulation disorders | ARYX THERAPEUTICS, INC. (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2161261-A1 | Materials and methods for treating coagulation disorders | Aryx Therapeutics (US) | 2010-03-10 | — | — | EP | disclosed |
| EP-1735296-B1 | MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS | ARYX THERAPEUTICS (US) | 2009-12-09 | — | — | EP | disclosed |