⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27908221 | 0.72 | — | — | |
| SCHEMBL720183 | 0.72 | — | — | |
| Allylamine SCHEMBL3842065 | 0.69 | ALDH1A1 (0.69) | — | |
| SCHEMBL27675575 | 0.69 | — | — | |
| Allyl Alcohol SCHEMBL11499496 | 0.69 | TSHR (0.69) | — | |
| Allylamine SCHEMBL3842062 | 0.69 | — | — | |
| SCHEMBL15106936 | 0.69 | — | — | |
| SCHEMBL16150548 | 0.69 | TSHR (0.39) | — | |
| Allylamine SCHEMBL1975499 | 0.69 | — | — | |
| SCHEMBL16149056 | 0.67 | TSHR (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49834-E1 | Jak1 selective inhibitors and uses thereof | Hangzhou Highlightll Pharmaceutical Co., Ltd. (US) | 2024-02-13 | — | — | US | claimed |
| CN-113214278-A | Novel selective inhibitors of Jak1 and uses thereof | 杭州高光制药有限公司 | 2021-08-06 | — | — | CN | claimed |
| US-10738060-B2 | JAK1 selective inhibitors and uses thereof | TLL Pharmaceutical, LLC (US) | 2020-08-11 | — | — | US | claimed |
| US-20190256523-A1 | NOVEL JAK1 SELECTIVE INHIBITORS AND USES THEREOF | HANGZHOU HIGHLIGHTII PHARMACEUTICAL CO., LTD (CN) | 2019-08-22 | — | — | US | claimed |
| EP-0660835-A4 | PROCESS FOR PREPARING CERTAIN PYRROLO 3,4- -I(B))QUINOLINES, CERTAIN 1H-PYRANO 3',4':6,7)INDOLIZINO 1,2--I(B))QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO 1,2--I(B))QUINOLIN-9(11H)-ONES. | — | 1995-08-16 | — | — | EP | claimed |
| EP-0660835-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO 3,4- $i(b)]QUINOLINES, CERTAIN 1H-PYRANO 3',4':6,7]INDOLIZINO 1,2-$i(b)]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO 1,2-$i(b)]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-07-05 | — | — | EP | claimed |
| WO-1994005672-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO[3,4- b]QUINOLINES, CERTAIN 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO[1,2-b]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-17 | — | — | WO | claimed |
| CN-108366994-B | Novel selective inhibitors of Jak1 and uses thereof | 杭州高光制药有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-113214278-A | Novel selective inhibitors of Jak1 and uses thereof | 杭州高光制药有限公司 | 2021-08-06 | — | — | CN | disclosed |
| US-10738060-B2 | JAK1 selective inhibitors and uses thereof | TLL Pharmaceutical, LLC (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190256523-A1 | NOVEL JAK1 SELECTIVE INHIBITORS AND USES THEREOF | HANGZHOU HIGHLIGHTII PHARMACEUTICAL CO., LTD (CN) | 2019-08-22 | — | — | US | disclosed |
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |
| US-20160051531-A1 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN INC (US) | 2016-02-25 | — | — | US | disclosed |
| US-4115400-A | 1-Azoniabicyclo[3.1.0]hexanes | ELI LILLY AND COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4099012-A | ANTIANXIETY, ANTIDEPRESSANT | CIBA-GEIGY CORPORATION (US) | 1978-07-04 | — | — | US | disclosed |
| US-4081450-A | 1,3,4-Trisubstituted-4-arylpiperidines and their preparation | ELI LILLY AND COMPANY (US) | 1978-03-28 | — | — | US | disclosed |
| US-4028381-A | ANTIANXIETY AND ANTIDEPRESSANT AGENTS | CIBA-GEIGY CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-4022801-A | ANTIANXIETY AND ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1977-05-10 | — | — | US | disclosed |
| US-4022800-A | ANTIANXIETY AND ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1977-05-10 | — | — | US | disclosed |
| US-3933802-A | New sulphamoylbenzoic acid amides | CIBA-GEIGY CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |