Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.59 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648615 | 0.86 | LRRK2 (0.79) | LRRK2CYP3A4SLCO1B1KCNH2 | |
| SCHEMBL1647109 | 0.84 | LRRK2 (0.65) | LRRK2SRPK3CYP3A4SLCO1B1 | |
| SCHEMBL1647847 | 0.84 | LRRK2 (0.79) | LRRK2SRPK3CYP3A4SLCO1B1 | |
| SCHEMBL1647748 | 0.81 | LRRK2 (0.81) | LRRK2SRPK3CYP3A4SLCO1B1 | |
| SCHEMBL10322017 | 0.79 | LRRK2 (0.60) | LRRK2SRPK3CYP3A4SLCO1B1 | |
| SCHEMBL10820439 | 0.79 | LRRK2 (0.83) | LRRK2SRPK3CYP3A4SLCO1B1 | |
| SCHEMBL6917702 | 0.77 | LRRK2 (0.67) | LRRK2CYP3A4SLCO1B1KCNH2 | |
| SCHEMBL1646947 | 0.77 | LRRK2 (0.61) | LRRK2CYP3A4SLCO1B1KCNH2 | |
| SCHEMBL6918692 | 0.76 | LRRK2 (0.80) | LRRK2CYP3A4SLCO1B1KCNH2 | |
| SCHEMBL6917773 | 0.76 | LRRK2 (0.65) | LRRK2CYP3A4SLCO1B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |