Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918063 | 0.90 | LRRK2 (0.76) | LRRK2IKBKETBK1GSK3BDYRK1A | |
| SCHEMBL29857044 | 0.90 | LRRK2 (0.76) | LRRK2IKBKETBK1GSK3BDYRK1A | |
| SCHEMBL1648615 | 0.86 | LRRK2 (0.79) | LRRK2CYP3A4SLCO1B1KCNH2 | |
| SCHEMBL1646768 | 0.85 | LRRK2 (0.51) | LRRK2IKBKETBK1GSK3BDYRK1A | |
| SCHEMBL10322212 | 0.84 | LRRK2 (0.53) | LRRK2IKBKETBK1GSK3BDYRK1A | |
| SCHEMBL6917773 | 0.84 | LRRK2 (0.65) | LRRK2CYP3A4SLCO1B1KCNH2 | |
| SCHEMBL1647863 | 0.83 | LRRK2 (0.53) | LRRK2IKBKETBK1KCNH2GSK3B | |
| SCHEMBL25951821 | 0.83 | LRRK2 (0.65) | LRRK2CYP3A4SLCO1B1IKBKETBK1 | |
| SCHEMBL10192760 | 0.81 | LRRK2 (0.54) | LRRK2CYP3A4SLCO1B1IKBKETBK1 | |
| SCHEMBL1647109 | 0.79 | LRRK2 (0.65) | LRRK2CYP3A4SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-08-13 | — | — | EP | disclosed |
| EP-2483254-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8778939-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2014-07-15 | — | — | US | disclosed |
| US-8778939-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2014-07-15 | — | — | US | disclosed |
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20120184553-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-07-19 | — | — | US | disclosed |
| US-20120184553-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-07-19 | — | — | US | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184553-A1 | NOVEL COMPOUNDS | LRRK2, PARK7, PINK1 | LRRK2 1/4885CYP3A4 4694/4885SLCO1B1 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.