SCHEMBL1648480

SCHEMBL1648480

O=C1OC(c2ccc(O)cc2)(c2ccc(O)cc2)c2cccc(Br)c21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYMS P04818 4/20 0.58
MEN1 O00255 2/20 0.58
LMNA P02545 2/20 0.58
KMT2A Q03164 2/20 0.58
ALDH1A1 P00352 2/20 0.58
ALOX15 P16050 2/20 0.58
HSD17B10 Q99714 2/20 0.58
ESR1 P03372 1/20 0.58
TP53 P04637 1/20 0.58
CYP3A4 P08684 1/20 0.58
MAPT P10636 1/20 0.58
TSHR P16473 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
ESR2 Q92731 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
GPR55 Q9Y2T6 1/20 0.58
DHFR P00374 4/20 0.57
MMP2 P08253 1/20 0.51
MMP3 P08254 1/20 0.51
MMP9 P14780 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3378483 0.84 TYMS (0.61) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL9395623 0.83 TYMS (0.65) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL11443116 0.81 TYMS (0.58) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL9258357 0.81 TYMS (0.58) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL5999539 0.81 ALDH1A1 (0.66) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL5992456 0.80 MEN1 (0.50) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL2519554 0.79 ALDH1A1 (0.55) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL5931812 0.79 TYMS (0.55) TYMSMEN1LMNAKMT2AALDH1A1
SCHEMBL1908131 0.79 HPGD (0.63) TYMSMEN1LMNAKMT2AALDH1A1
Phenolphthalein SCHEMBL9163222 0.77 MAPT (0.78) TYMSMEN1LMNAKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019196731-A1 SUBSTITUTED PYRAZOLYL PYRAZOLE SULFONYLUREA COMPOUND OR PESTICIDE ACCEPTABLE SALT OR COMPOSITION THEREOF AND USE THEREOF 海利尔药业集团股份有限公司 2019-10-17 WO disclosed
WO-2019148849-A1 TERNARY HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 2019-08-08 WO disclosed
US-7927613-B2 Pharmaceutical co-crystal compositions UNIVERSITY OF SOUTH FLORIDA (US) 2011-04-19 US disclosed
WO-1994012858-A1 SOLID STATE DEVICE FOR MONITORING INTEGRAL VALUES OF TIME AND TEMPERATURE OF STORAGE OF PERISHABLES JP LABORATORIES, INC. (US) 1994-06-09 WO disclosed
EP-0446153-A2 Photorefractive system and process for its use EASTMAN KODAK COMPANY (US) 1991-09-11 EP disclosed