SCHEMBL1648508

SCHEMBL1648508

c1ccc2c(c1)Cc1cccnc1O2

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.59
MAOB P27338 1/20 0.59
ABCC4 O15439 1/20 0.52
PTGS1 P23219 1/20 0.52
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
LMNA P02545 3/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
SHMT2 P34897 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31151882 1.00 MAOA (0.59) MAOAMAOBABCC4PTGS1GAA
SCHEMBL2760383 0.80 ABCC4 (0.59) MAOAMAOBABCC4PTGS1LMNA
SCHEMBL651524 0.80 MAOB (0.44) MAOAMAOBABCC4PTGS1LMNA
SCHEMBL8106789 0.80 ABCC4 (0.43) MAOAMAOBABCC4PTGS1
SCHEMBL7789411 0.80 ABCC4 (0.46) MAOAMAOBABCC4PTGS1LMNA
SCHEMBL22472604 0.79 MAOA (0.52) MAOAMAOBABCC4PTGS1GAA
SCHEMBL813060 0.77 MAOA (0.59) MAOAMAOBABCC4PTGS1GAA
SCHEMBL29588358 0.77 MAOA (0.59) MAOAMAOBABCC4PTGS1GAA
SCHEMBL7022937 0.77 ABCC4 (0.37) MAOAMAOBABCC4PTGS1GAA
SCHEMBL10812388 0.77 MAOA (0.53) MAOAMAOBABCC4PTGS1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118345390-A Method for preparing carbonyl compound by electrocatalytic oxidation of benzyl C-H bond by pyridine nitrogen oxide 浙江大学 2024-07-16 CN claimed
CN-113121550-B Preparation method of 7-ethoxycarbonyl-5H-benzopyran [2,3-b ] pyridine-5-ketone 武汉先路医药科技股份有限公司 2024-04-02 CN claimed
CN-113121550-A Preparation method of 7-ethoxycarbonyl-5H-benzopyran [2,3-b ] pyridine-5-ketone 武汉先路医药科技股份有限公司 2021-07-16 CN claimed
EP-0991793-B1 METHOD FOR PREPARING 2-ARYL OR 2-HETEROCYCLYL CHIRAL PROPIONIC ACIDS AND THEIR ESTERS CT NAT DE BR LA RECH SCIENT (FR) 2001-12-05 EP claimed
US-6294069-B1 MIXTURE OF PROPIONIC ACID DERIVATIVE IS ELECTROCHEMICALLY REDUCED IN THE PRESENCE OF NICKEL COMPLEX CATALYST AND SUPPORTING ELECTROLYTE IN ELECTROLYSIS CELL PROVIDED WITH ELECTRODES, PRODUCT IS HYDROLYZED OR TRANSESTERIFIED CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2001-09-25 US claimed
EP-0485173-A2 Esters and amides of substituted fused ring phenyl acetic acids FGN, INC. (US) 1992-05-13 EP claimed
JP-4095094-A None JP disclosed
JP-4288080-A None JP disclosed
CN-119661548-A Pranoprofen Process for the preparation of intermediates 辰欣药业股份有限公司 2025-03-21 CN disclosed
US-20240343738-A1 Method for preparing pranoprofen and composition comprising pranoprofen and impurity SHENYANG XINGQI PHARMACEUTICAL CO., LTD. (CN) 2024-10-17 US disclosed
CN-118345390-A Method for preparing carbonyl compound by electrocatalytic oxidation of benzyl C-H bond by pyridine nitrogen oxide 浙江大学 2024-07-16 CN disclosed
CN-113845427-B Aryl alcohol, aryl ketone, aryl carboxylic acid compound, and synthetic method and application thereof 华东师范大学 2024-06-25 CN disclosed
EP-4361155-A1 METHOD FOR PREPARING PRANOPROFEN AND COMPOSITION CONTAINING PRANOPROFEN AND IMPURITY Shenyang Xingqi Pharmaceutical Co., Ltd. (CN) 2024-05-01 EP disclosed
EP-0828702-A1 PROCESS FOR RESOLVING CHIRAL ACIDS WITH 1-AMINOINDAN-2-OLS SEPRACOR, INC. (US) 1998-03-18 EP disclosed
WO-1996036584-A1 PROCESS FOR RESOLVING CHIRAL ACIDS WITH 1-AMINOINDAN-2-OLS SEPRACOR, INC. (US) 1996-11-21 WO disclosed
JP-H04288080-A PRODUCTION OF BENZOPYRANO(2,3-B)PYRIDINE DERIVATIVE YODOGAWA SEIYAKU KK 1992-10-13 JP disclosed
EP-0485173-A2 Esters and amides of substituted fused ring phenyl acetic acids FGN, INC. (US) 1992-05-13 EP disclosed
JP-H0495094-A SYNTHESIS OF BENZOPYRANO(2,3-B)PYRIDINE DERIVATIVE YODOGAWA SEIYAKU KK 1992-03-27 JP disclosed
US-3931205-A ANTIRHEUMATIC, ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1976-01-06 US disclosed
US-3931199-A ANTIALLERGY YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240343738-A1 Method for preparing pranoprofen and composition comprising pranoprofen and impurity CYP3A5, CYP3A43, CYP4A11 MAOA 1014/4885MAOB 637/4885ABCC4 3340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.