SCHEMBL1648552 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	METAP2	P50579	7/20	0.47

▸	MAPT	P10636	5/20	0.34

▸	TSHR	P16473	4/20	0.34

▸	ALOX15	P16050	3/20	0.34

▸	HSD17B10	Q99714	2/20	0.34

▸	TP53	P04637	2/20	0.34

▸	MEN1	O00255	2/20	0.33

▸	KMT2A	Q03164	2/20	0.33

▸	GAA	P10253	2/20	0.33

▸	MAPK1	P28482	2/20	0.33

▸	ALDH1A1	P00352	1/20	0.33

▸	FLT3	P36888	1/20	0.32

▸	SMN1; SMN2	Q16637	1/20	0.32

▸	SLC2A1	P11166	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1648937	0.92	METAP2 (0.52)	METAP2MAPTHSD17B10MEN1KMT2A
SCHEMBL462403	0.92	METAP2 (0.52)	METAP2MAPTHSD17B10MEN1KMT2A
SCHEMBL435999	0.92	METAP2 (0.52)	METAP2MAPTHSD17B10MEN1KMT2A
SCHEMBL1648328	0.90	METAP2 (0.54)	METAP2MAPTTSHRALOX15HSD17B10
SCHEMBL14717898	0.89	METAP2 (0.54)	METAP2FLT3
SCHEMBL14717899	0.89	METAP2 (0.54)	METAP2FLT3
SCHEMBL436523	0.83	METAP2 (0.57)	METAP2FLT3
SCHEMBL14717510	0.83	METAP2 (0.57)	METAP2FLT3
SCHEMBL462796	0.83	METAP2 (0.57)	METAP2FLT3
SCHEMBL14717275	0.82	METAP2 (0.63)	METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2486004-A2	SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME	Zafgen Corporation (US)	2012-08-15	—	—	EP	disclosed
WO-2011044506-A2	SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME	ZAFGEN CORPORATION (US)	2011-04-14	—	—	WO	disclosed