Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | TLR2 | O60603 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18885626 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL19643024 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL19658311 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL15773229 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL19643062 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL19016246 | 0.87 | HPGD (0.41) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL1578132 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL15744056 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL16574886 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHTTCA2CA12 | |
| SCHEMBL30360564 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDHTTCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015155998-A1 | ANTI-HER3 ANTIBODY-DRUG CONJUGATE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-15 | — | — | WO | disclosed |
| WO-2014057687-A1 | ANTIBODY-DRUG CONJUGATE | 第一三共株式会社 (JP) | 2014-04-17 | — | — | WO | disclosed |