Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.36 |
| ▸ | EPOR | P19235 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.32 |
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18885626 | 0.95 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL19643024 | 0.93 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL17168383 | 0.91 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL19658311 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL29467598 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDHTTEPORFOLH1 | |
| SCHEMBL16574886 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL15773229 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL19016246 | 0.87 | HPGD (0.41) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL16485544 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTCA12CA1 | |
| SCHEMBL1578132 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3463413-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | Merck Sharp & Dohme Corp. (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017205309-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-30 | — | — | WO | disclosed |