Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4642441 | 0.80 | GAA (0.53) | GAAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL28812738 | 0.79 | DYRK2 (0.35) | GAAALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL6140694 | 0.71 | NOX1 (0.41) | GAAMEN1KMT2AMAPTNOX1 | |
| SCHEMBL30876858 | 0.71 | NOX1 (0.41) | GAAMEN1KMT2AMAPTNOX1 | |
| SCHEMBL27826779 | 0.71 | RPS6KA3 (0.35) | MAPTNOX1BCHEACHEHTR2C | |
| SCHEMBL4488749 | 0.70 | GAA (0.52) | GAAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL30549 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL31003509 | 0.66 | GAA (0.41) | GAAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL10670210 | 0.66 | ALOX15 (0.39) | GAAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29452948 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| EP-3759092-A1 | COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION | University College Cardiff Consultants Ltd (GB) | 2021-01-06 | — | — | EP | disclosed |
| WO-2018146486-A1 | AMPA RECEPTOR POTENTIATORS | THE UNIVERSITY OF SUSSEX (GB) | 2018-08-16 | — | — | WO | disclosed |
| CN-102600171-A | Structure utilizing benzothiadiazine and pyrazolothiadiazine derivatives as aldose reductase inhibitor, synthetic method and application | BEIJING INST TECHNOLOGY | 2012-07-25 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| EP-1026950-A1 | TREATMENT OF SCHIZOPHRENIA WITH AMPAKINES AND NEUROLEPTICS | CORTEX PHARMACEUTICALS, INC. (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999021422-A1 | TREATMENT OF SCHIZOPHRENIA WITH AMPAKINES AND NEUROLEPTICS | CORTEX PHARMACEUTICALS, INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| WO-1998012185-A1 | BENZOTHIADIAZIDE DERIVATIVES AND THEIR USE AS ALLOSTERIC UP-MODULATORS OF THE AMPA RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-03-26 | — | — | WO | disclosed |
| EP-0636124-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021170-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |