Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | FABP7 | O15540 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16781651 | 0.86 | KMT2A (0.49) | KMT2AEPHX2CASP3 | |
| SCHEMBL16781650 | 0.86 | KMT2A (0.49) | KMT2AEPHX2CASP3 | |
| SCHEMBL16781639 | 0.79 | KMT2A (0.44) | KMT2AEPHX2 | |
| SCHEMBL16781640 | 0.79 | KMT2A (0.44) | KMT2AEPHX2 | |
| SCHEMBL15341324 | 0.76 | KMT2A (0.51) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL8248504 | 0.75 | KMT2A (0.39) | KMT2AEPHX2 | |
| SCHEMBL23111835 | 0.75 | KMT2A (0.74) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL30946961 | 0.73 | EPHX2 (0.57) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL3026492 | 0.73 | EPHX2 (0.57) | KMT2AEPHX2CASP3FABP7FABP5 | |
| SCHEMBL3026489 | 0.73 | EPHX2 (0.57) | KMT2AEPHX2CASP3FABP7FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082876-A1 | 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT | Genentech, Inc. (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-3033111-A1 | 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT | Genentech, Inc. (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015095212-A1 | 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT | GENENTECH, INC. (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015023355-A1 | 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT | GENENTECH, INC. (US) | 2015-02-19 | — | — | WO | disclosed |