Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21292981 | 0.88 | BACE1 (0.39) | SYKARPOLBMKNK1MKNK2 | |
| SCHEMBL17909864 | 0.81 | SYK (0.48) | SYKARKDM4ELMNAPOLB | |
| SCHEMBL16487124 | 0.80 | SYK (0.43) | SYKARKDM4ELMNAPOLB | |
| SCHEMBL17909862 | 0.74 | SYK (0.48) | SYKARKDM4ELMNAPOLB | |
| SCHEMBL20767113 | 0.74 | MKNK1 (0.51) | KDM4EPOLBMKNK1MKNK2NTRK1 | |
| SCHEMBL15730144 | 0.74 | POLB (0.47) | KDM4ELMNAPOLBCASP6CYP1A2 | |
| SCHEMBL23199045 | 0.73 | NTRK1 (0.52) | KDM4EPOLBMKNK1MKNK2CCNC | |
| SCHEMBL31119750 | 0.73 | CCNC (0.53) | MKNK1MKNK2CCNCCDK8NTRK1 | |
| SCHEMBL17909895 | 0.71 | SYK (0.42) | SYKCYP1A2TGFBR1KDRPIK3CB | |
| Acetic Acid SCHEMBL27846617 | 0.71 | NTRK1 (0.50) | KDM4EPOLBMKNK1MKNK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015022546-A1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2015-02-19 | — | — | WO | disclosed |