Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21292979 | 0.88 | SRC (0.40) | SYKSRCPOLBKDRPIK3CD | |
| SCHEMBL17909862 | 0.82 | SYK (0.48) | SYKSRCPOLBKDM4ELMNA | |
| SCHEMBL16487127 | 0.80 | SYK (0.43) | SYKSRCPOLBKDM4ELMNA | |
| SCHEMBL16881110 | 0.76 | AR (0.46) | SRCKDRPIK3CDABL1EGFR | |
| SCHEMBL17909864 | 0.75 | SYK (0.48) | SYKPOLBKDM4ELMNACASP6 | |
| SCHEMBL27907482 | 0.73 | MEN1 (0.54) | SRCPOLBKDM4ELMNAKDR | |
| SCHEMBL17909893 | 0.73 | SYK (0.41) | SYKSRCKDRPIK3CDABL1 | |
| SCHEMBL17637874 | 0.72 | RIPK2 (0.71) | SRCKDRKCNH2TGFBR1RIPK2 | |
| SCHEMBL17909879 | 0.70 | SRC (0.40) | SYKSRCKDM4EKDRPIK3CD | |
| SCHEMBL30163484 | 0.70 | POLB (0.55) | POLBKDM4ELMNACASP6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015022546-A1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2015-02-19 | — | — | WO | disclosed |