Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.66 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648747 | 1.00 | LRRK2 (0.66) | LRRK2SGMS2MET | |
| SCHEMBL6917993 | 1.00 | LRRK2 (0.66) | LRRK2SGMS2MET | |
| SCHEMBL10322891 | 0.83 | LRRK2 (0.68) | LRRK2SGMS2MET | |
| SCHEMBL10321935 | 0.83 | LRRK2 (0.68) | LRRK2SGMS2MET | |
| SCHEMBL10322501 | 0.82 | LRRK2 (0.64) | LRRK2SGMS2MET | |
| SCHEMBL10322888 | 0.82 | LRRK2 (0.64) | LRRK2SGMS2MET | |
| SCHEMBL1647152 | 0.80 | LRRK2 (1.00) | LRRK2SGMS2 | |
| SCHEMBL1648049 | 0.80 | TSHR (0.63) | — | |
| SCHEMBL1649387 | 0.78 | LRRK2 (0.61) | LRRK2SGMS2MET | |
| SCHEMBL6918348 | 0.78 | LRRK2 (0.77) | LRRK2SGMS2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |