Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.52 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.52 |
| ▸ | CHRNG | P07510 | 1/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | CHRND | Q07001 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648747 | 0.80 | LRRK2 (0.66) | — | |
| SCHEMBL6917993 | 0.80 | LRRK2 (0.66) | — | |
| SCHEMBL1648751 | 0.80 | LRRK2 (0.66) | — | |
| SCHEMBL29039242 | 0.77 | CHRNB4 (0.67) | CHRNB4CHRNA3NR1H4 | |
| SCHEMBL29039239 | 0.77 | CHRNB4 (0.67) | CHRNB4CHRNA3NR1H4 | |
| SCHEMBL905236 | 0.77 | CHRNA3 (0.81) | CHRNB4CHRNA3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL905201 | 0.77 | CHRNA3 (0.81) | CHRNB4CHRNA3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL3942452 | 0.77 | CHRNA3 (0.81) | CHRNB4CHRNA3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL26999492 | 0.77 | CHRNB4 (0.63) | CHRNB4CHRNA3 | |
| SCHEMBL29039262 | 0.77 | CHRNB4 (0.63) | CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |