Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.58 |
| ▸ | JAK2 | O60674 | 12/20 | 0.58 |
| ▸ | JAK3 | P52333 | 6/20 | 0.58 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19884797 | 0.92 | JAK1 (0.60) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884845 | 0.91 | JAK1 (0.59) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884841 | 0.86 | JAK1 (0.68) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884836 | 0.85 | JAK1 (0.60) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884823 | 0.85 | JAK1 (0.61) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884849 | 0.85 | JAK1 (0.61) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL10062200 | 0.84 | JAK3 (0.60) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL353202 | 0.84 | JAK3 (0.60) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL19884825 | 0.83 | JAK1 (0.58) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884802 | 0.82 | JAK1 (0.57) | JAK1JAK2JAK3BTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828181-B1 | PYRROLO[2,3-B]PYRIDIN-4-YL-AMINES AND PYRROLO[2M3-B]PYRIMIDIN-4-YL-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORP (US) | 2015-02-18 | — | — | EP | disclosed |