Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.68 |
| ▸ | JAK2 | O60674 | 13/20 | 0.68 |
| ▸ | JAK3 | P52333 | 6/20 | 0.57 |
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19884836 | 0.89 | JAK1 (0.60) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884797 | 0.87 | JAK1 (0.60) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884845 | 0.87 | JAK1 (0.59) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL352920 | 0.86 | JAK2 (0.68) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL16488303 | 0.86 | JAK1 (0.58) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884849 | 0.84 | JAK1 (0.61) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL19884823 | 0.84 | JAK1 (0.61) | JAK1JAK2JAK3BTKTYK2 | |
| SCHEMBL351447 | 0.84 | JAK3 (0.59) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL10062096 | 0.84 | JAK3 (0.59) | JAK1JAK2JAK3TYK2PKN2 | |
| SCHEMBL19884812 | 0.84 | JAK1 (0.54) | JAK1JAK2JAK3BTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671882-B1 | pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2m3-b]pyrimidin-4-yl-amines as janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2018-02-21 | — | — | EP | disclosed |