Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bepotastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 6/20 | 0.50 |
| ▸ | DRD2 | P14416 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bepotastine SCHEMBL1287638 | 1.00 | BCHE (0.50) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL29357467 | 1.00 | BCHE (0.50) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL28344323 | 1.00 | BCHE (0.50) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL4005011 | 0.94 | BCHE (0.47) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL726880 | 0.94 | BCHE (0.55) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL5151702 | 0.94 | BCHE (0.55) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL29459 | 0.94 | BCHE (0.55) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL30200949 | 0.94 | BCHE (0.55) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL29440897 | 0.94 | BCHE (0.55) | BCHEDRD2NPC1MLNRNR1I2 | |
| Bepotastine SCHEMBL4001237 | 0.94 | BCHE (0.46) | BCHEDRD2NPC1MLNRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106309389-A | Bepotastine besilate composition and preparation prepared thereby | 重庆华邦制药有限公司 | 2017-01-11 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |