Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bepotastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 9/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bepotastine SCHEMBL4005011 | 0.99 | BCHE (0.47) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL1649103 | 0.94 | BCHE (0.50) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL29357467 | 0.94 | BCHE (0.50) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL28344323 | 0.94 | BCHE (0.50) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL1287638 | 0.94 | BCHE (0.50) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL9533303 | 0.91 | BCHE (0.45) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL29459 | 0.89 | BCHE (0.55) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL726880 | 0.89 | BCHE (0.55) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL20907012 | 0.89 | ADRA1D (0.51) | BCHEDRD2ADRA1DADRA1AADRA1B | |
| Bepotastine SCHEMBL30200949 | 0.89 | BCHE (0.55) | BCHEDRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009075504-A2 | CRYSTALLINE FORM OF BEPOTASTINE P-TOLUENESULFONATE, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | HANMI PHARM. CO., LTD. (KR) | 2009-06-18 | — | — | WO | claimed |
| WO-2009075504-A2 | CRYSTALLINE FORM OF BEPOTASTINE P-TOLUENESULFONATE, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | HANMI PHARM. CO., LTD. (KR) | 2009-06-18 | — | — | WO | disclosed |