Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | GRN | P28799 | 2/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.34 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LOX | P28300 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16493542 | 0.85 | MAPT (0.42) | ALDH1A1HTTNPSR1MAPTMEN1 | |
| SCHEMBL16493544 | 0.85 | MAPT (0.42) | ALDH1A1HTTNPSR1MAPTMEN1 | |
| SCHEMBL4003246 | 0.84 | MAPK10 (0.36) | MAPK10MAPK8GAAMAPTMEN1 | |
| SCHEMBL4008389 | 0.81 | ROCK1 (0.45) | MAP2K7BRAFKDRMAPK14TNNI3K | |
| SCHEMBL3512431 | 0.79 | KDM4E (0.54) | GRNSORT1ALDH1A1HTTGAA | |
| SCHEMBL3511097 | 0.73 | CDK8 (0.53) | — | |
| SCHEMBL2194318 | 0.73 | NR4A1 (0.45) | BRAFALDH1A1GAAMAPTGFER | |
| SCHEMBL2194186 | 0.73 | HDAC2 (0.38) | BRAF | |
| SCHEMBL3511358 | 0.71 | HSPB1 (0.46) | ALDH1A1HTTGAANPSR1KDM4E | |
| SCHEMBL3511355 | 0.71 | HSPB1 (0.46) | ALDH1A1HTTGAANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675552-B1 | PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-04-11 | — | — | EP | disclosed |