Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5436667 | 0.88 | KMT2A (0.53) | NPC1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL16493577 | 0.84 | KDM4E (0.53) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3862704 | 0.81 | L3MBTL1 (0.51) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14562082 | 0.80 | KMT2A (0.53) | NPC1KDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL1930688 | 0.77 | NPC1 (0.55) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1928775 | 0.77 | NPC1 (0.67) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1931179 | 0.77 | L3MBTL1 (0.52) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1930084 | 0.76 | L3MBTL1 (0.67) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1930037 | 0.76 | L3MBTL1 (0.65) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1930507 | 0.76 | NPC1 (0.65) | NPC1RAB9AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968972-B1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-28 | — | — | EP | disclosed |