Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | PAICS | P22234 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL16493685 | 1.00 | HTR7 (0.42) | HTR7CNR1PAICSBRD4UTS2R | |
| Bicarbonate SCHEMBL16493677 | 0.93 | HTR7 (0.43) | HTR7CNR1PAICSBRD4UTS2R | |
| Bicarbonate SCHEMBL16493849 | 0.92 | CNR1 (0.48) | HTR7CNR1ATMCNR2FAAH | |
| Hydrochloric Acid SCHEMBL544475 | 0.87 | PAICS (0.36) | HTR7PAICSATMSLC6A9KDM4E | |
| Hydrochloric Acid SCHEMBL544474 | 0.87 | PAICS (0.36) | HTR7PAICSATMSLC6A9KDM4E | |
| Hydrochloric Acid SCHEMBL4046584 | 0.87 | PAICS (0.36) | HTR7PAICSATMSLC6A9KDM4E | |
| Hydrochloric Acid SCHEMBL544476 | 0.87 | PAICS (0.36) | HTR7PAICSATMSLC6A9KDM4E | |
| Bicarbonate SCHEMBL16493748 | 0.87 | HTR7 (0.42) | HTR7CNR1PAICSBRD4UTS2R | |
| Bicarbonate SCHEMBL16493561 | 0.87 | ATM (0.42) | HTR7CNR1PAICSUTS2RHTR1A | |
| Bicarbonate SCHEMBL16493556 | 0.87 | HTR7 (0.42) | HTR7CNR1PAICSBRD4UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059508-B1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI SA (FR) | 2012-04-11 | — | — | EP | claimed |