Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 10/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694560 | 0.82 | ALDH1A1 (0.55) | BTKCNR1MEN1MAPTHTT | |
| SCHEMBL20337764 | 0.81 | ACP1 (0.38) | KDM4EMAPTKMT2A | |
| SCHEMBL29526189 | 0.81 | ACP1 (0.38) | KDM4EMAPTKMT2A | |
| SCHEMBL19691685 | 0.81 | EGFR (0.40) | PAK1NOS1NOS2BTKEGFR | |
| SCHEMBL1783130 | 0.81 | KMT2A (0.43) | PAK1NOS1NOS2BTKEGFR | |
| SCHEMBL1693347 | 0.80 | MAPT (0.52) | MEN1MAPTHTTKMT2A | |
| SCHEMBL1693350 | 0.80 | MAPT (0.52) | MEN1MAPTHTTKMT2A | |
| SCHEMBL12936052 | 0.78 | KDM4E (0.43) | KDM4EMEN1MAPTKMT2A | |
| SCHEMBL27907279 | 0.78 | SSTR4 (0.37) | PAK1NOS1NOS2SLC6A12BTK | |
| SCHEMBL14768725 | 0.77 | KMT2A (0.45) | KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397482-A1 | Heteroaryl imidazolone derivatives as jak inhibitors | Almirall, S.A. (ES) | 2011-12-21 | — | — | EP | disclosed |