Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1649460 | 0.92 | METAP2 (0.43) | METAP2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL6844921 | 0.92 | METAP2 (0.43) | METAP2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL1649459 | 0.92 | METAP2 (0.43) | METAP2SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL1648328 | 0.91 | METAP2 (0.54) | METAP2MAPTMEN1KMT2AALOX15 | |
| SCHEMBL14717297 | 0.89 | METAP2 (0.48) | METAP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL14717298 | 0.89 | METAP2 (0.48) | METAP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL462417 | 0.83 | METAP2 (0.42) | METAP2 | |
| SCHEMBL14717510 | 0.83 | METAP2 (0.57) | METAP2 | |
| SCHEMBL462418 | 0.83 | METAP2 (0.42) | METAP2 | |
| SCHEMBL436523 | 0.83 | METAP2 (0.57) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |