Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorthalidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 1.00 |
| ▸ | CA2 | P00918 | 9/20 | 1.00 |
| ▸ | CA7 | P43166 | 3/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 1.00 |
| ▸ | CA3 | P07451 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | CA4 | P22748 | 2/20 | 1.00 |
| ▸ | CA6 | P23280 | 2/20 | 1.00 |
| ▸ | CA5A | P35218 | 2/20 | 1.00 |
| ▸ | CA9 | Q16790 | 2/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorthalidone SCHEMBL26234 | 1.00 | CA1 (1.00) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL4425734 | 1.00 | CA1 (1.00) | CA1CA2CA7CA12CA3 | |
| (R)-Chlorthalidone SCHEMBL30872862 | 1.00 | CA1 (1.00) | CA1CA2CA7CA12CA3 | |
| (R)-Chlorthalidone SCHEMBL827454 | 1.00 | CA1 (1.00) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL29687442 | 1.00 | CA1 (1.00) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL28520875 | 0.99 | CA1 (0.98) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL7305527 | 0.95 | CA1 (0.91) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL29127388 | 0.92 | CA1 (0.84) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL28297372 | 0.86 | CA1 (0.73) | CA1CA2CA7CA12CA3 | |
| Chlorthalidone SCHEMBL4984545 | 0.86 | CA1 (0.73) | CA1CA2CA7CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3401 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3934654-B1 | ISTAROXIME OR ITS METABOLITE PST-3093 FOR USE AS INTRAVENOUS FORMULATION FOR THE TREATMENT OF ACUTE HEART FAILURE (AHF) | WINDTREE THERAPEUTICS INC (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| EP-4426368-B1 | APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT | GAMBRO LUNDIA AB (SE) | 2025-11-26 | — | — | EP | claimed |
| EP-3877402-B1 | COMBINATION TREATMENT FOR HYPERTENSION | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2025-07-16 | — | — | EP | claimed |
| EP-3968964-B1 | METHOD FOR PRODUCING NANOPARTICLES | LEON NANODRUGS GMBH (DE) | 2024-07-10 | — | — | EP | claimed |
| US-20240123204-A1 | CARDIOVASCULAR DISEASE MEDICATION ADMINISTRATION METHODS | AORTO MEDICAL LLC. (MA) | 2024-04-18 | — | — | US | claimed |
| EP-3737676-B1 | ACETAL COMPOUNDS AND THERAPEUTIC USES THEREOF | LIGAND PHARM INC (US) | 2024-03-06 | — | — | EP | claimed |
| US-20240033258-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ADDICTION AND OTHER NEUROPSYCHIATRIC DISORDERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY & AGRICULTURAL & MECHANICAL COLLEGE (US) | 2024-02-01 | — | — | US | claimed |
| EP-3498297-B1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM | STALICLA S A (CH) | 2023-06-21 | — | — | EP | claimed |
| EP-3599243-B1 | 17BETA-HETEROCYCLYL-DIGITALIS LIKE COMPOUNDS FOR THE TREATMENT OF HEART FAILURE | CVIE THERAPEUTICS LTD (TW) | 2023-04-12 | — | — | EP | claimed |
| EP-0083779-A1 | Hyperuretic agents | Beyer, Karl H., Jr. (US) | 1983-07-20 | — | — | EP | claimed |
| EP-0083923-A2 | Aminoacyl-containing dipeptide derivatives useful as antihypertensives | MERCK & CO. INC. (US) | 1983-07-20 | — | — | EP | claimed |
| EP-0081094-A1 | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents | MERCK & CO. INC. (US) | 1983-06-15 | — | — | EP | claimed |
| EP-0079522-A1 | N-Carboxymethyl(amidino)lysyl-proline antihypertensive agents | MERCK & CO. INC. (US) | 1983-05-25 | — | — | EP | claimed |
| EP-0061186-A1 | Dipeptides containing thialysine and homologs as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0061187-A1 | Bicyclic lactams as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | claimed |
| EP-0049505-A2 | Substituted caprolactam derivatives, a process for preparing and a pharmaceutical composition containing the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-14 | — | — | EP | claimed |
| EP-0046289-A2 | Substituted enantholactam derivatives as antihypertensives, a process for preparing and a pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | claimed |
| EP-0046291-A2 | Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | claimed |