Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorthalidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.73 |
| ▸ | CA2 | P00918 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | CA12 | O43570 | 1/20 | 0.73 |
| ▸ | CA3 | P07451 | 1/20 | 0.73 |
| ▸ | CA4 | P22748 | 1/20 | 0.73 |
| ▸ | CA6 | P23280 | 1/20 | 0.73 |
| ▸ | CA5A | P35218 | 1/20 | 0.73 |
| ▸ | CA7 | P43166 | 1/20 | 0.73 |
| ▸ | CA9 | Q16790 | 1/20 | 0.73 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.73 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-Chlorthalidone SCHEMBL30872862 | 0.86 | CA1 (1.00) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL29687442 | 0.86 | CA1 (1.00) | CA1CA2MAPTCA12CA3 | |
| (R)-Chlorthalidone SCHEMBL827454 | 0.86 | CA1 (1.00) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL26234 | 0.86 | CA1 (1.00) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL164949 | 0.86 | CA1 (1.00) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL4425734 | 0.86 | CA1 (1.00) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL28520875 | 0.84 | CA1 (0.98) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL7305527 | 0.82 | CA1 (0.91) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL4984541 | 0.79 | CA12 (0.67) | CA1CA2MAPTCA12CA3 | |
| Chlorthalidone SCHEMBL29127388 | 0.78 | CA1 (0.84) | CA1CA2MAPTCA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080066741-A1 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | HUNTER, CHARLES ERIC | 2008-03-20 | — | — | US | claimed |
| EP-4255541-A1 | PRODUCT DELIVERY DEVICES AND METHODS | Breathe Restore, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022118225-A1 | PRODUCT DELIVERY DEVICES AND METHODS | BREATHE RESTORE, INC. (US) | 2022-06-09 | — | — | WO | disclosed |
| US-9554989-B2 | Silk reservoirs for drug delivery | TRUSTEES OF TUFTS COLLEGE (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150045764-A1 | SILK RESERVOIRS FOR DRUG DELIVERY | TRUSTEES OF TUFTS COLLEGE | 2015-02-12 | — | — | US | disclosed |
| EP-2827884-A1 | SILK RESERVOIRS FOR DRUG DELIVERY | Trustees Of Tufts College (US) | 2015-01-28 | — | — | EP | disclosed |
| WO-2013148158-A1 | LASER-ACTUATED THERAPEUTIC NANOPARTICLES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2013142119-A1 | SILK RESERVOIRS FOR DRUG DELIVERY | TRUSTEES OF TUFTS COLLEGE (US) | 2013-09-26 | — | — | WO | disclosed |