Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PTAFR | P25105 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16496067 | 0.97 | HPGDS (0.57) | HPGDSSMN1; SMN2MAPTMAPK14CAMK2D | |
| SCHEMBL16495815 | 0.89 | HPGDS (0.60) | HPGDSMAPTPTAFRHDAC1BAZ2B | |
| SCHEMBL16496426 | 0.89 | HPGDS (0.52) | HPGDSSMN1; SMN2MAPTMAPK14PTAFR | |
| SCHEMBL16495439 | 0.89 | HPGDS (0.56) | HPGDSMAPTNPC1RAB9APTAFR | |
| SCHEMBL16496040 | 0.88 | HPGDS (0.58) | HPGDSMAPK14PTAFRHIF1AHDAC1 | |
| SCHEMBL16495974 | 0.88 | HPGDS (0.53) | HPGDSSMN1; SMN2MAPTMAPK14NPC1 | |
| SCHEMBL16495503 | 0.87 | HPGDS (0.52) | HPGDSMAPK14CAMK2DPTAFRHDAC1 | |
| SCHEMBL13572932 | 0.87 | HPGDS (0.60) | HPGDSMAPTPTAFRTP53LMNA | |
| SCHEMBL16495773 | 0.87 | HPGDS (0.54) | HPGDSSMN1; SMN2MAPTNPC1PTAFR | |
| SCHEMBL16495755 | 0.86 | NPC1 (0.54) | HPGDSSMN1; SMN2MAPTMAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885SMN1; SMN2 1659/4885MAPT 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.