Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | PTAFR | P25105 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495497 | 0.87 | HPGDS (0.55) | RAB9ANPC1SMN1; SMN2PTAFRHDAC2 | |
| SCHEMBL16495388 | 0.86 | TRPV1 (0.58) | RAB9ANPC1SMN1; SMN2PTAFRMAPT | |
| SCHEMBL16495906 | 0.86 | HPGDS (0.64) | RAB9ANPC1SMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL16496007 | 0.83 | NPC1 (0.61) | RAB9ANPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL16495626 | 0.81 | NT5E (0.64) | RAB9ASMN1; SMN2KDM4ELMNAPOLB | |
| SCHEMBL16495740 | 0.80 | TRPV1 (0.48) | SMN1; SMN2PTAFRPOLBMAPTHPGDS | |
| SCHEMBL16495479 | 0.80 | HPGDS (0.77) | KDM4ELMNAHPGDSROCK1VNN1 | |
| SCHEMBL16495895 | 0.80 | NAMPT (0.56) | RAB9ANPC1SMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL16495662 | 0.80 | HPGDS (0.65) | LMNAHPGDSNAMPT | |
| SCHEMBL16495457 | 0.79 | MAPT (0.46) | PTAFRLMNAPOLBMAPTHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | RAB9A 2122/4885NPC1 236/4885SMN1; SMN2 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.