Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | EIF4E | P06730 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495831 | 0.88 | HPGDS (0.73) | HPGDSMAOBLMNAEPHX2HDAC4 | |
| SCHEMBL16495706 | 0.88 | HPGDS (0.56) | HPGDSPRKAA2MAOBEIF4ELMNA | |
| SCHEMBL16496066 | 0.88 | HPGDS (0.71) | HPGDSMCHR1HTR2CPRKAA2NPC1 | |
| SCHEMBL16496425 | 0.87 | HPGDS (0.63) | HPGDSMCHR1HTR2CPRKAA2NPC1 | |
| SCHEMBL16495549 | 0.84 | HPGDS (0.65) | HPGDSMCHR1HTR2CNPC1RXFP1 | |
| SCHEMBL16495958 | 0.82 | HPGDS (0.63) | HPGDSMCHR1HTR2CPRKAA2NPC1 | |
| SCHEMBL16496124 | 0.82 | HPGDS (0.63) | HPGDSMCHR1HTR2CPRKAA2NPC1 | |
| SCHEMBL16495576 | 0.82 | HPGDS (0.82) | HPGDSMCHR1HTR2CPRKAA2NPC1 | |
| SCHEMBL13876544 | 0.82 | MCHR1 (0.54) | HPGDSMCHR1HTR2CPRKAA2NPC1 | |
| SCHEMBL16496093 | 0.81 | HPGDS (0.56) | HPGDSMAOBEIF4ELMNAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885CXCR2 768/4885MCHR1 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.