Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Naphazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.97 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphazoline SCHEMBL29369882 | 0.98 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL34532 | 0.98 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL26087856 | 0.97 | TAAR1 (0.97) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL12481545 | 0.97 | TAAR1 (0.97) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL24153 | 0.97 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL29389962 | 0.97 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL7039049 | 0.90 | TAAR1 (0.84) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL28732221 | 0.90 | TAAR1 (0.84) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL16241749 | 0.89 | TAAR1 (0.82) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL506167 | 0.88 | TAAR1 (0.80) | TAAR1CYP2D6NISCHMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114652717-A | New application of naphazoline hydrochloride medicine | 忻佑康医药科技(南京)有限公司 | 2022-06-24 | — | — | CN | claimed |
| CN-122075696-A | Application of MSR1 inhibitor in preparation of anti-tumor immunopotentiator | — | 2026-05-26 | — | — | CN | disclosed |
| CN-118852014-A | Resource utilization method of naphazoline synthetic waste | 湖北华丹医药科技股份有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-114652717-B | Pharmaceutical application of naphazoline hydrochloride | 忻佑康医药科技(南京)有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-110041261-B | Preparation method of naphazoline hydrochloride | 广东先强药业有限公司 | 2022-06-24 | — | — | CN | disclosed |
| CN-114652717-A | New application of naphazoline hydrochloride medicine | 忻佑康医药科技(南京)有限公司 | 2022-06-24 | — | — | CN | disclosed |
| CN-107389826-A | A kind of naphcon and its detection method about material | 山东绅联药业有限公司 | 2017-11-24 | — | — | CN | disclosed |
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| US-20130137099-A1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS | KYOTO UNIVERSITY (JP) | 2013-05-30 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| CN-101196495-B | Method for measuring content of triamcinolone acetonide chloromycetin solution | JUNYONG AN | 2010-11-17 | — | — | CN | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| CN-101196495-A | Method for measuring content of triamcinolone acetonide chloromycetin solution | JUNYONG AN (CN) | 2008-06-11 | — | — | CN | disclosed |