Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Naphazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphazoline SCHEMBL29369882 | 1.00 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL26087856 | 0.98 | TAAR1 (0.97) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL12481545 | 0.98 | TAAR1 (0.97) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL24153 | 0.98 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL29389962 | 0.98 | TAAR1 (1.00) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL1649580 | 0.98 | TAAR1 (0.97) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL7039049 | 0.92 | TAAR1 (0.84) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL28732221 | 0.92 | TAAR1 (0.84) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL16241749 | 0.90 | TAAR1 (0.82) | TAAR1CYP2D6NISCHMAPK1LMNA | |
| Naphazoline SCHEMBL506167 | 0.89 | TAAR1 (0.80) | TAAR1CYP2D6NISCHMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14172 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137558-A1 | OPHTHALMIC DEVICE | Able Tx Ltd. (IL) | 2026-05-21 | — | — | US | claimed |
| US-20260137763-A1 | Anti-Tick Vaccine Compositions and Related Methods | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF NORTHERN ARIZONA UNIVERSITY (US) | 2026-05-21 | — | — | US | claimed |
| US-12605345-B2 | Transdermal drug delivery system | BioPhysics Pharma, Inc. (US) | 2026-04-21 | — | — | US | claimed |
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-20260048096-A1 | METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS | STEALTH BIOTHERAPEUTICS INC. (US) | 2026-02-19 | — | — | US | claimed |
| EP-4691568-A2 | LOW-DOSE BRIMONIDINE COMBINATIONS AND USES THEREOF | Eye Therapies, LLC (US) | 2026-02-11 | — | — | EP | claimed |
| WO-2025262047-A1 | NEW ANESTHETIC COMPOSITION | ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS (FR) | 2025-12-26 | — | — | WO | claimed |
| US-20250381195-A1 | Methods of Treating Diabetic Macular Edema | UNM RAINFOREST INNOVATIONS (US) | 2025-12-18 | — | — | US | claimed |
| EP-0170193-A2 | Feedstuff additive for the growth promoting of agricultural useful animals | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1986-02-05 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0025269-B1 | ANTI-DIARRHOEA VETERINARY COMPOSITION | BEECHAM GROUP PLC (GB) | 1985-11-13 | — | — | EP | claimed |
| EP-0023359-B1 | POWDERY PHARMACEUTICAL COMPOSITION AND POWDERY PREPARATION FOR APPLICATION TO THE NASAL MUCOSA, AND METHOD FOR ADMINISTRATION THEREOF | TEIJIN LIMITED (JP) | 1984-04-18 | — | — | EP | claimed |
| EP-0086428-A1 | Antidiarrhoea veterinary composition, its production and oral doser containing it | BEECHAM GROUP PLC (GB) | 1983-08-24 | — | — | EP | claimed |
| US-4294829-A | Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof | TEIJIN LIMITED (JP) | 1981-10-13 | — | — | US | claimed |
| US-4255439-A | Means and method for aiding individuals to stop smoking | COOPER IRVING | 1981-03-10 | — | — | US | claimed |
| EP-0023359-A2 | Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof | TEIJIN LIMITED (JP) | 1981-02-04 | — | — | EP | claimed |
| US-4246394-A | PROMOTER FOR CROSSLINKING | VEBA-CHEMIE AKTIENGESELLSCHAFT (DE) | 1981-01-20 | — | — | US | claimed |
| US-3933999-A | 1-METHYL-2-(2-(ALPHA-METHYL-P -CHLORODIPHENYLMETHOXY)ETHYL)PYRROLIDONE, RHINITIS, VASOCONSTRICTOR | SANDOZ LTD., (SANDOZ AG) (CH) | 1976-01-20 | — | — | US | claimed |