Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pentostatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA known ✓ | P00813 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | AMPD3 | Q01432 | 2/20 | 0.67 |
| ▸ | AMPD2 | Q01433 | 6/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | AMPD1 | P23109 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentostatin SCHEMBL14031902 | 1.00 | ADA (1.00) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Pentostatin SCHEMBL2818 | 1.00 | ADA (1.00) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Pentostatin SCHEMBL5549091 | 1.00 | ADA (1.00) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Pentostatin SCHEMBL2045053 | 1.00 | ADA (1.00) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Pentostatin SCHEMBL28078896 | 0.88 | ADA (0.77) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Coformycin SCHEMBL11184406 | 0.81 | ADA (1.00) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Coformycin SCHEMBL14031897 | 0.81 | ADA (1.00) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Promethazine SCHEMBL28095270 | 0.80 | ADA (0.65) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Pentostatin SCHEMBL28265748 | 0.80 | ADA (0.64) | ADAADORA3ADORA2AADORA1AMPD3 | |
| Pentostatin SCHEMBL28197957 | 0.79 | ADA (0.63) | ADAADORA3ADORA2AADORA1AMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 958 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260090278-A1 | FIXED LAYER OF MAGNETIC TUNNEL JUNCTION, MAGNETIC MEMORY CHIP, AND METHOD FOR MANUFACTURING MAGNETIC TUNNEL JUNCTION | YANGTZE DELTA GRADUATE SCHOOL OF BEIJING INSTITUTE OF TECHNOLOGY (JIAXING) (CN) | 2026-03-26 | — | — | US | claimed |
| US-12433941-B2 | Exosomal nucleic acid vaccine modularly configured to harness multiple antigen presentation mechanisms | THE JOHNS HOPKINS UNIVERSITY (US) | 2025-10-07 | — | — | US | claimed |
| CN-120074278-A | Cross bending type magnetostriction-epoxy resin composite energy collector | 河北工业大学 | 2025-05-30 | — | — | CN | claimed |
| WO-2025111589-A1 | COMPOSITIONS AND METHODS FOR ENHANCING DRUG RESISTANCE IN CELLS | MEDICI THERAPEUTICS, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| EP-4302829-B1 | PEPTIDE FOR USE IN PREVENTING OR TREATING MACULAR DEGENERATION | STEALTH BIOTHERAPEUTICS INC (US) | 2025-05-21 | — | — | EP | claimed |
| CN-120019953-A | Wei Gensi, and preparation method and application thereof | 广东美的智能科技有限公司 | 2025-05-20 | — | — | CN | claimed |
| WO-2025077721-A1 | MYT1 INHIBITOR BASED ON FUSED THIAZOLE OR PYRIDINE RING | PHARMAENGINE, INC. (CN) | 2025-04-17 | — | — | WO | claimed |
| US-12274715-B2 | Method for maximizing coronavirus killing activity of high-density lipoproteins, and pharmaceutical composition for preventing or treating COVID-19 | RAYDEL KOREA CO., LTD. (KR) | 2025-04-15 | — | — | US | claimed |
| US-12278031-B2 | Soft magnetic composite materials and methods and powders for producing the same | CARPENTER TECHNOLOGY CORPORATION (US) | 2025-04-15 | — | — | US | claimed |
| CN-119816292-A | Sterol-based ionizable lipids and lipid nanoparticles comprising the same | 先进核糖核酸疫苗(ARV)技术股份有限公司 | 2025-04-11 | — | — | CN | claimed |
| CN-114438545-A | Bimetal doped Ni3S2Preparation method of oxygen evolution electrocatalyst | 河北工业大学 | 2022-05-06 | — | — | CN | claimed |
| WO-2022094405-A1 | BREATH BIOMARKERS OF SARS-COV-2 IN CHILDREN AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OF COVID-19 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2022-05-05 | — | — | WO | claimed |
| WO-2022076600-A1 | MASSIVELY SCALABLE VIRAL TESTING AND ASYMPTOMATIC SURVEILLANCE | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2022-04-14 | — | — | WO | claimed |
| CN-216228577-U | Clamp and grinding device | 上海飞机制造有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-114293105-A | Cr-Mo-Co-V bainite high-temperature bearing steel and preparation method thereof | 清华大学 | 2022-04-08 | — | — | CN | claimed |
| CN-113292338-B | Ba-Co-V based low dielectric low-firing microwave ceramic material and preparation method thereof | 电子科技大学 | 2022-03-15 | — | — | CN | claimed |
| US-11246887-B2 | Prevention of infection by highly pathogenic viruses using topical application of povidone-iodine on mucous membranes | FIREBRICK PHARMA LIMITED (AU) | 2022-02-15 | — | — | US | claimed |
| CN-114041220-A | Magnetic current collector, negative pole piece using same, lithium metal battery and electronic device | 宁德新能源科技有限公司 | 2022-02-11 | — | — | CN | claimed |
| CN-110139692-A | For adjusting the heteroaryl amines and its preparation method and purposes of hedgehog approach | 财团法人生物技术开发中心 | 2019-08-16 | — | — | CN | claimed |
| US-9540412-B2 | Methods of preparing targeted aptamer prodrugs | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-01-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260090278-A1 | FIXED LAYER OF MAGNETIC TUNNEL JUNCTION, MAGNETIC MEMORY CHIP, AND METHOD FOR MANUFACTURING MAGNETIC TUNNEL JUNCTION | MAP2K6, MAP2K1, MAP2K2 | ADA 1576/4885ADORA3 3954/4885ADORA2A 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.