Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.81 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.81 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.81 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.81 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.81 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | GLA | P06280 | 3/20 | 0.80 |
| ▸ | GAA | P10253 | 3/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | RAF1 | P04049 | 7/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.76 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.76 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.76 |
| ▸ | BRAF | P15056 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593317 | 0.93 | KDM4E (0.91) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL413667 | 0.90 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL29103864 | 0.89 | KDM4E (0.83) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL2949385 | 0.87 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL7228717 | 0.87 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL2148151 | 0.87 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL12561579 | 0.87 | KDM4E (0.76) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL17002188 | 0.87 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL29642733 | 0.86 | KDM4E (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL12561695 | 0.86 | KDM4E (0.80) | MAPK14MAPK13MAPK12MAPK11ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038261-A1 | HETEROCYCLIC KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011038261-A1 | HETEROCYCLIC KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-03-31 | — | — | WO | disclosed |